publication . Doctoral thesis . 2009

Metal Particles – Hazard or Risk? Elaboration and Implementation of a Research Strategy from a Surface and Corrosion Perspective

Midander, Klara;
Open Access English
  • Published: 01 Jan 2009
  • Publisher: KTH, Korrosionslära
  • Country: Sweden
Abstract
Do metal particles (including particles of pure metals, alloys, metal oxides and compounds) pose a hazard or risk to human health? In the light of this question, this thesis summarizes results from research conducted on metal particles, and describes the elaboration and implementation of an in vitro test methodology to study metal release from particles through corrosion and dissolution processes in synthetic biological media relevant for human exposure through inhalation/ingestion and dermal contact. Bioaccessible metals are defined as the pool of released metals from particles that potentially could be made available for absorption by humans or other organisms...
Subjects
free text keywords: ferro-chromium alloy, metal particles, bioaccessibility, chemical speciation, dermal contact, surface oxide, in-vitro testing, cu, copper, comet assay, intracellular, ultrafine, in vitro, A549, cytotoxicity, DNA damage, nanoparticles, particle characterization, artificial sweat, nickel release, nickel powder particles, particle loadings, release kinetics, surface area, copper release, powder particles, synthetic body fluids, simulation of interstitial lung conditions, skin contact, metal release, stainless steel, particles, test method, Surface and colloid chemistry, Yt- och kolloidkemi, Analytical chemistry, Analytisk kemi, Spectroscopy, Spektroskopi
Related Organizations
Download from
28 references, page 1 of 2

Selected references............................................................................... 8 2 An initial approach to assess metal release from particles..............10 2.1 A bioaccessibility test should be easy to perform and modify,

efective analytical techniques. (paper I) ...................................... 12 2.2 Several exposure parameters are crucial for measuring metal release

from particles. (papers I-IV)........................................................ 14 2.3 The nature of the material of particles is decisive for the metal

release process. (papers I-IV) ....................................................... 18 2.4 Metal release from particles is influenced by the test media

composition. (papers II, III)........................................................ 21 2.5 Metal release from particles is influenced by particle size.

(paper III)...................................................................................24

Selected references............................................................................. 29 3 An interdisciplinary approach to assess metal release and toxicity of nano- and micrometer-sized particles ..............................................30 3.4 Nanoparticles are more toxic than micrometer-sized particles and

metals. (paper V) ........................................................................ 43 3.5 Copper nanoparticles are made available to cells via release

(papers V, VI) .............................................................................45 4.2 Generated bioaccessibility data has to be based on scientifically

testing. (papers VII, VIII) ...........................................................55 4.3 Products and test items have to be thoroughly characterized from a

bulk and surface perspective. (papers VII, VIII) ..........................57 4.4 Bioaccessible data on main and minor alloy constituents should be

generated. (papers VII, VIII).......................................................60 4.5 The bioavailable fraction of the bioaccessible pool of metals should

be assessed. (papers VII, VIII) .....................................................64

Selected references.............................................................................67 5 Acknowledgement........................................................................68 Limbach LK, Li Y, Grass RN, Brunner TJ, Hintermann MA, Muller M, Gunther D, Stark WJ. 2005. Oxide

Low Concentrations. Environ. Sci. Technol. 39:9370-9376 Limbach LK, Wick P, Manser P, Grass RN, Bruinink A, Stark WJ. 2007. Exposure of engineered nanopar-

28 references, page 1 of 2
Any information missing or wrong?Report an Issue