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Involvement of RF-amide peptide receptors in pain modulation and opioid induced hyperalgesia

Authors: Ayachi, Safia;

Involvement of RF-amide peptide receptors in pain modulation and opioid induced hyperalgesia

Abstract

La douleur est un problème de santé publique majeur qui réduit la qualité de vie des patients et engendre un coût élevé pour la société. Malgré les efforts fournis pour développer de nouveaux analgésiques, les opiacés restent le moyen le plus efficace pour réduire la douleur moyenne à intense. Cependant, leur utilisation prolongée est responsable du développement d’une tolérance à leurs effets analgésiques et d’une hypersensibilité à la douleur (hyperalgésie). Il a été proposé que ces phénomènes pourraient résulter de l'activation d’un système anti-opioïde tel que celui des récepteurs RF-amide, mais leurs mécanismes d’action sont encore mal compris. L'objectif de ce projet a ainsi été d'étudier l'implication des récepteurs RF-amide NPFFR1, NPFFR2 et GPR103a dans le développement de l'hyperalgésie induite par les opiacés. Allant du niveau cellulaire, en s’intéressant à l’expression des ARNm, à la modulation de l’activité neuronale induite par le 26RFa, jusqu’à un niveau plus intégré via une approche in vivo et l’étude des seuils nociceptifs et de la douleur chez la souris ; ce travail a permis d’avoir une vision globale des effets du système RF-amide et principalement de GPR103a. En abordant la question des effets secondaires associés aux traitements chroniques opiacés, ce projet pourrait conduire à l'élaboration de stratégies de traitement de la douleur prometteuses.

Pain is a major health problem that reduces quality of life and imparts high social and economic costs. Despite efforts to develop new analgesics, opiates remain the most effective way to reduce severe pain. However, their prolonged use is associated with the development of analgesic tolerance and hypersensitivity to pain (hyperalgesia). It has been proposed that these phenomena would result from the activation of anti-opioid system like RF-amide receptors system, but their mechanism of action is still poorly understood. The objective of this project was to study the involvement of NPFFR1, NPFFR2 and GPR103a receptors in the development of opioidinduced hyperalgesia. This work gave an overall view of the effects of the RF-amide system and mainly of GPR103a, ranging from the cellular level, to the expression of mRNAs, to the modulation of the 26RFa-induced neuronal activity, up to an integrated level via an in vivo approach and the study of nociceptive thresholds and pain in mice. By addressing the issue of side effects associated with opioid chronic treatments, this project may lead to the development of promising strategies for pain treatment.

Related Organizations
Keywords

Nociception, Douleur, Récepteurs RFamide, Opioid-induced hyperalgesia, [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, RF-amide receptor, Pain, GPR103, 26RFa, Hyperalgésie induite par les opiacés, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]

32 references, page 1 of 4

1. Récepteurs et peptides RF-amide ....................................................................................... 195

2. Récepteurs et peptides opiacés .......................................................................................... 197 2. Voies de la douleur Les voies de la douleur ont été fortement étudiées et un grand nombre de revues décrivent avec précision le cheminement qu'emprunte l'information nociceptive jusqu'à devenir douleur (D'Mello and Dickenson, 2008; Basbaum et al., 2009; Dubin and Patapoutian, 2010; Tracey and Dickenson, 2012; Mertens et al., 2014).

1. Boutens L, Stienstra R. Adipose tissue macrophages: going off track during obesity. Diabetologia. 2016;59(5):879-894. [OpenAIRE]

2. Rosen ED, Spiegelman BM. What we talk about when we talk about fat. Cell. 2014;156(1-2):20-44.

3. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112(12):1796-1808.

4. Amano SU, et al. Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation. Cell Metab. 2014;19(1):162-171.

5. Röszer T. Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms. Mediators Inflamm. 2015;2015:816460. [OpenAIRE]

6. Quillet R, Ayachi S, Bihel F, Elhabazi K, Ilien B, Simonin F. RF-amide neuropeptides and their receptors in Mammals: Pharmacological properties, drug development and main physiological functions. Pharmacol Ther. 2016;160:84-132. [OpenAIRE]

7. Murase T, Arima H, Kondo K, Oiso Y. Neuropeptide FF reduces food intake in rats. Peptides. 1996;17(2):353-354. [OpenAIRE]

8. Lefrere I, et al. Neuropeptide AF and FF modulation of adipocyte metabolism. Primary insights from functional genomics and effects on beta-adrenergic responsiveness. J Biol Chem. 2002;277(42):39169-39178.

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  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Funded by
EC| ESATM
Project
ESATM
Embryonic stem cell origin of the adipose tissue macrophages
  • Funder: European Commission (EC)
  • Project Code: 655598
  • Funding stream: H2020 | MSCA-IF-EF-ST
,
NIH| Defining Islet Heterogeneity Using Single Islet Transcriptomics
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1UC4DK104155-01
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
iis
,
NIH| CANCER CENTER SUPPORT
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P30CA014520-18
  • Funding stream: NATIONAL CANCER INSTITUTE
iis
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