publication . Article . Other literature type . 2015

Neuroprotective effects of (Val8)GLP-1-Glu-PAL in the MPTP Parkinson’s disease mouse model

Zhang, YanFang; Chen, YiMei; Li, Lin; Hölscher, Christian;
Open Access
  • Published: 15 Oct 2015 Journal: Behavioural Brain Research, volume 293, pages 107-113 (issn: 0166-4328, Copyright policy)
  • Publisher: Elsevier BV
  • Country: United Kingdom
Abstract
Abstract Glucagon-like peptide 1 (GLP-1) is a hormone and a growth factor. GLP-1 mimetics are currently on the market as treatments for type 2 diabetes. They also have shown neuroprotective properties in animal models of neurodegenerative disorders. In addition, the GLP-1 mimetic exendin-4 has shown protective effects in animal models of Parkinson’s disease (PD), and a first clinical trial in PD patients showed promising results. (Val8)GLP-1-glu-PAL is a new GLP-1 analogue which has a longer biological half-life than exendin-4. We previously showed that (Val8)GLP-1-glu-PAL has neuroprotective properties. Here we tested the drug in the 1-methyl-4-phenyl-1,2,3,6-t...
Subjects
Medical Subject Headings: endocrine systemdigestive, oral, and skin physiologyhormones, hormone substitutes, and hormone antagonists
free text keywords: Behavioral Neuroscience, Endocrinology, medicine.medical_specialty, medicine, Tyrosine hydroxylase, Caspase 3, Internal medicine, Parkinson's disease, medicine.disease, MPTP, chemistry.chemical_compound, chemistry, Neuroprotection, Neuroinflammation, Growth factor, medicine.medical_treatment, Psychology, Substantia nigra
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publication . Article . Other literature type . 2015

Neuroprotective effects of (Val8)GLP-1-Glu-PAL in the MPTP Parkinson’s disease mouse model

Zhang, YanFang; Chen, YiMei; Li, Lin; Hölscher, Christian;