publication . Doctoral thesis . 2008

Functional characterization of the mammalian iAAA protease subunit, YME1L

Majczak, Joanna;
Open Access English
  • Published: 01 Jan 2008
  • Country: Germany
Abstract
The iAAA protease is an ATP-dependent proteolytic complex in the mitochondrial inner membrane and belongs to the highly conserved family of AAA proteins. In the yeast Saccharomyces cerevisiae, the iAAA protease is a homo-oligomeric complex composed of Yme1p subunits which are active in the intermembrane space and mediate protein quality control. Yeast cells lacking Yme1p are characterized by pleiotropic phenotypes including a respiratory deficiency at elevated temperature and an aberrant mitochondrial morphology. However, the molecular basis of the different yeast yme1 phenotypes has not been completely understood. Human YME1L was shown to be the ortholog of the...
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free text keywords: ddc:570
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