publication . Conference object . 2015

High-field functional MRI (7 Tesla) mapping of Tonotopy in Human primary auditory cortex in patients with unilateral hearing loss and tinnitus.

Ghazaleh, Naghmeh; Van der Zwaag, Wietske; Maire, Raphael; Saenz, Melissa;
Open Access
  • Published: 08 Feb 2015
  • Country: Switzerland
Abstract
Tinnitus, the chronic perception of ringing or other phantom sounds, is typically associated with hearing loss. Recent studies in mouse models have alleviated tinnitus symptom by reversing plastic reorganization observed in the tonotopic maps of primary auditory cortex (A1) (Engineer et al. Nature, 2011, Yang et al. PNAS 2011). Here, we use high-resolution functional MRI at 7 Tesla (1.5 mm isotropic voxels) to test whether human tinnitus sufferers also have similar disorganization within the auditory cortical maps. Our fMRI mapping paradigm (Da Costa et al. J Neurosci 2011) allows fine-scale imaging of two primary tonotopic maps in human cortex corresponding to ...
Subjects
Medical Subject Headings: otorhinolaryngologic diseases
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