Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability.
Alzheimer Disease/metabolism; Alzheimer Disease/pathology; Alzheimer Disease/physiopathology; Amyloid beta-Peptides/metabolism; Amyloid beta-Peptides/toxicity; Animals; Animals, Newborn; Astrocytes/drug effects; Astrocytes/metabolism; Brain/metabolism; Brain/pathology; Brain/physiopathology; Cell Communication/drug effects; Cell Communication/physiology; Cell Survival/drug effects; Cell Survival/physiology; Cells, Cultured; Energy Metabolism/drug effects; Energy Metabolism/physiology; Free Radicals/metabolism; Glucose/metabolism; Glutathione/metabolism; Hydrogen Peroxide/metabolism; Mice; Nerve Degeneration/metabolism; Nerve Degeneration/pathology; Nerve Degeneration/physiopathology; Neurons/metabolism; Oxidative Stress/drug effects; Oxidative Stress/physiology; Peptide Fragments/toxicity; Phenotype; Phosphatidylinositol 3-Kinases/antagonists & inhibitors; Phosphatidylinositol 3-Kinases/metabolism
mesheuropmc: mental disorders
Amyloid-beta (Abeta) peptides play a key role in the pathogenesis of Alzheimer's disease and exert various toxic effects on neurons; however, relatively little is known about their influence on glial cells. Astrocytes play a pivotal role in brain homeostasis, contributi...