publication . Article . 2004

A novel 13 residue acyclic peptide from the marine snail, Conus monile, targets potassium channels

Sadasivannair Sudarslal; Govindaswamy Singaravadivelan; Palanisamy Ramasamy; Kuppanna Ananda; Siddhartha P Sarma; Sujit K Sikdar; K.S Krishnan; Padmanabhan Balaram;
  • Published: 01 May 2004
  • Publisher: Elsevier BV
  • Country: India
Abstract
A novel 13-residue peptide Mo1659 has been isolated from the venom of a vermivorous cone snail, Conus monile. HPLC fractions of the venom extract yielded an intense UV absorbing fraction with a mass of 1659 Da. De novo sequencing using both matrix assisted laser desorption and ionization and electrospray MS/MS methods together with analysis of proteolytic fragments successfully yielded the amino acid sequence, HGGSWYRFPWGY-NH2. This was further confirmed by comparison with the chemically synthesized peptide and by conventional Edman sequencing. Mo1659 has an unusual sequence with a preponderance of aromatic residues and the absence of apolar, aliphatic residues ...
Subjects
free text keywords: Molecular Biophysics Unit, Biophysics, Cell Biology, Biochemistry, Molecular Biology, Conotoxin, Cone snail, Venom, Conus, biology.organism_classification, biology, Peptide sequence, Edman degradation, Mass spectrometry, Peptide, chemistry.chemical_classification, chemistry
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publication . Article . 2004

A novel 13 residue acyclic peptide from the marine snail, Conus monile, targets potassium channels

Sadasivannair Sudarslal; Govindaswamy Singaravadivelan; Palanisamy Ramasamy; Kuppanna Ananda; Siddhartha P Sarma; Sujit K Sikdar; K.S Krishnan; Padmanabhan Balaram;