Thermodynamic Effects of Replacements of Pro Residues in Helix Interiors of Maltose-Binding Protein

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Prajapati, RS; Lingaraju, GM; Bacchawat, Kiran; Surolia, Avadhesha; Varadarajan, Raghavan;
(2003)
  • Publisher: Wiley-Liss, Inc.
  • Subject: Molecular Biophysics Unit

Introduction of Pro residues into helix interiors results in protein destabilization. It is currently unclear if the converse substitution (i.e., replacement of Pro residues that naturally occur in helix interiors would be stabilizing). Maltose-binding protein is a larg... View more
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