Caractérisation métabolomique des tissus épilectogènes par spectroscopie RMN à haute résolution à l'angle magique (RMN HRMAS) : applications à l'épilepsie temporale humaine et animale

Doctoral thesis French OPEN
Detour , Julien;
(2013)
  • Publisher: HAL CCSD
  • Subject: [ SDV.MHEP.AHA ] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] | Lithium-pilocarpine | Temporal Lobe Epilepsy | Microondes | Lithium-pilocaprine | Carbone 13 | Neurométabolisme | Carbon 13 | Nuclear Magnetic Resonance | [ SDV.NEU.NB ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology | Metabolomic | Métabolomique | Epilepsie temporale | Angle magique | Magic Angle Spinning | Résonance magnétique nucléaire

Metabolomics relates to the identification and quantification of metabolites in biological samples. This discipline is part of an approach known under the term of "systems biology". High Resolution Nuclear Magnetic Resonance Spectroscopy at Magic Angle Spinning (HRMAS N... View more
  • References (83)
    83 references, page 1 of 9

    (1) Andrew, E. R.; Bradbury, A.; Eades, R. G., Removal of dipolar broadening of Nuclear Magnetic Resonance spectra of solids by specimen rotation, Nature 1958, 183, 1802.

    (2) Lowe, I. J., Free induction decays of rotating solids, Phys. Rev. Lett. 1959, 2, 285.

    (3) Lippens, G.; Bourdonneau, M.; Dhalluin, C.; Warras, R.; Richert, T.; Seetharaman, C.; Boutillon, C.; Piotto, M., Study of compounds attached to solid supports using High Resolution Magic Angle Spinning NMR, Curr. Org. Chem. 1999, 3, 147.

    (4) Filtch, W. L.; Dettre, G.; Holmes, C. P.; Shoolery, J.; Keifer, P. A., HighResolution 1H NMR in Solid-Phase Oganic Synthesis, J. Org. Chem. 1994, 59, 7955.

    (5) Anderson, R. C.; Jarema, M. A.; Shapiro, M. J.; Stokes, J. P.; Zilliox, M., Analytical Techniques in Combinatorial Chemistry: MAS CH Correlation in SolventSwollen Resin, J. Org. Chem. 1995, 60, 2650.

    (6) Keifer, P. A., Influence of resin structure, tether lengh and solvent upon the High resolution 1H NMR spectra of solid-phase synthesis resin, J. Org. Chem. 1996, 61, 1558.

    (7) Doskocilova, D.; Tao, D.; Schneider, B., Effects of macroscopic spinning upon linewidth of NMR signals of liquids in magnetically inhomogeneous systems, Czech. J. Phys. B. 1975, 25, 202.

    (8) Elbayed, K.; Furrer, J.; Raya, J.; Hirschinger, J.; Bourdonneau, M.; Richert, T.; Piotto, M., Origin of the residual NMR linewidth of a peptide bound to a resin under magic angle spinning, Journal of Magnetic Resonance 1999, 136, 127.

    (9) Cheng, L. L.; Lean, C. L.; Bogdanova, A.; Wright Jr, S. C.; Ackerman, J. L.; Brady, T. J.; Garrido, L., Enhanced resolution of proton NMR spectra of malignant lymph nodes using magic-angle spinning, Magnetic Resonance in Medicine 1996, 36, 653.

    (10) Cheng, L. L.; Ma, M. J.; Becerra, L.; Ptak, T.; Tracey, I.; Lackner, A.; Gonza` lez, R. G., Quantitative neuropathology by high resolution magic angle spinning proton magnetic resonance spectroscopy, Proceedings of the National Academy of Sciences of the United States of America 1997, 94, 6408.

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