Contribution of tyrosine kinases to the selective orientation of human CD4+ bifunctional cloned T cells toward proliferation or cytolytic function.

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Eljaafari , A; Soula , M; Dorval , I; Pirenne , H; Quelvennec , E; Bernard , A.; Fagard , R; Sterkers , G;
  • Publisher: Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists
  • Subject: [ SDV ] Life Sciences [q-bio] | [ SDV.IMM ] Life Sciences [q-bio]/Immunology | [ SDV.BC ] Life Sciences [q-bio]/Cellular Biology

International audience; We show that T cell activation of human CD4+ cloned T cells through the CD2 molecule can induce either autocrine proliferation or cytolysis, depending on the pair of anti-CD2 mAbs used for stimulation, that is, D66/T11(1) or GT2/T11(1), respectiv... View more
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