publication . Article . 2006

Differential expression of AP-1 proteins in the pineal gland of Syrian hamster and rat may explain species diversity in Aa-nat gene expression.

Sinitskaya, Natalia; Salingre, Anthony; Klosen, Paul; Revel, Florent; Pevet, Paul; Simonneaux, Valérie;
Open Access English
  • Published: 01 Jan 2006
  • Publisher: HAL CCSD
  • Country: France
Abstract
Species differences have been reported for the nighttime regulation of arylalkylamine N-acetyltransferase (AA-NAT), the melatonin rhythm generating enzyme. In particular, de novo synthesis of stimulatory transcription factors is required for Aa-nat transcription in the Syrian hamster, but not in the rat pineal gland. The present work investigated the contribution of pCREB, c-FOS, c-JUN and JUN-B in the regulation of Aa-nat transcription in Syrian hamsters compared with rats. The nighttime patterns of CREB phosphorylation and regulation by norepinephrine observed in the Syrian hamster was similar to those reported in the rat. On the contrary, strong divergences i...
Subjects
Medical Subject Headings: endocrine system
free text keywords: [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
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publication . Article . 2006

Differential expression of AP-1 proteins in the pineal gland of Syrian hamster and rat may explain species diversity in Aa-nat gene expression.

Sinitskaya, Natalia; Salingre, Anthony; Klosen, Paul; Revel, Florent; Pevet, Paul; Simonneaux, Valérie;