publication . Doctoral thesis . 2013

Caractérisation métabolomique des tissus épilectogènes par spectroscopie RMN à haute résolution à l'angle magique (RMN HRMAS) : applications à l'épilepsie temporale humaine et animale

Detour, Julien;
Open Access French
  • Published: 02 Oct 2013
  • Publisher: HAL CCSD
  • Country: France
Abstract
Metabolomics relates to the identification and quantification of metabolites in biological samples. This discipline is part of an approach known under the term of "systems biology". High Resolution Nuclear Magnetic Resonance Spectroscopy at Magic Angle Spinning (HRMAS NMR) is a method for obtaining metabolic profiling in such sample. Temporal Lobe Epilepsy (TLE ) is a common focal epilepsy often associated with selective neuronal loss, reactive gliosis and specific cellular plasticity. A neurometabolic origin of this epilepsy is a major area of research. To date no characterization of human cerebral biopsy from TLE patients has been conducted using HRMAS NMR. In...
Subjects
free text keywords: Carbon 13, Lithium-pilocarpine, Metabolomic, Magic Angle Spinning, Nuclear Magnetic Resonance, Temporal Lobe Epilepsy, Lithium-pilocaprine, Carbone 13, Neurométabolisme, Microondes, Epilepsie temporale, Résonance magnétique nucléaire, Angle magique, Métabolomique, [ SDV.MHEP.AHA ] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [ SDV.NEU.NB ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
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