publication . Doctoral thesis . 2017

Pharmacological effects of palmitoylethanolamide on hypertension, insulin-resistance and obesity in murine models

Di Guida, Francesca;
Open Access Italian
  • Published: 07 Apr 2017
  • Country: Italy
Abstract
N-Palmitoylethanolamide (PEA) is an endogenous N-acylethanolamine, first identified in lipid extracts from brain, liver, and muscle of rat and guinea pig. PEA is formed “on demand” from membrane phospholipids and it is gaining ever-increasing interest not only for its anti-inflammatory and analgesic effects mediated by peroxisome-proliferator activated receptor (PPAR)-α, but also for its novel metabolic effects. Overweight and obesity are defined as abnormal or excessive fat accumulation that may impair health. Main consequence of obesity is cardiovascular disease (CVD). The sum of the risk factors that predisposes to CVD goes by the name of “metabolic syndrome”...
Subjects
Medical Subject Headings: food and beverages
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