publication . Book . 2012

Pharmaceutical cocrystals:formation mechanisms, solubility behaviour and solid-state properties

Alhalaweh, Amjad;
Restricted English
  • Published: 01 Apr 2012
  • Publisher: Luleå tekniska universitet
  • Country: Sweden
Abstract
The primary aim of pharmaceutical materials engineering is the successful formulation and process development of pharmaceutical products. The diversity of solid forms available offers attractive opportunities for tailoring material properties. In this context, pharmaceutical cocrystals, multicomponent crystalline materials with definite stoichiometries often stabilised by hydrogen bonding, have recently emerged as interesting alternative solid forms with potential for improving the physical and biopharmaceutical properties of a drug substance. There are, however, gaps in our understanding of the screening, scale-up and formulation operations required for effecti...
Subjects
free text keywords: /dk/atira/pure/core/keywords/Pharmacy, Pharmacy, Cocrystal, formation, solubility, pH, dissolution, surface properties, Pharmaceutics
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