publication . Doctoral thesis . 2013

Functional evaluation of HMGB1 as immune therapeutic effector molecule for cell-based vaccination strategies

Willenbrock, Saskia;
Open Access English
  • Published: 01 Jan 2013
  • Country: Germany
Abstract
Cancer is a leading cause of death worldwide although extensive research in human cancer medicine is carried out. To develop and improve molecular anticancer therapies, the characterisation of the structure and function of cancer-related genes and proteins is essential. The dog is one of the companion animals being considered as an invaluable model system. The spontaneous development of tumours in the context of an intact immune system in dogs and the striking similarities to human neoplasias offers new prospects for cancer immunotherapy in contrast to immunocompromised rodent models. Within this thesis, the molecular structure and function of the cancer related...
Subjects
free text keywords: cancer, animal model, dog, comparative genetics, RAGE, HMGB1, expression analyses, cancer immunotherapy, cytokine stimulation, in vivo cell tracking, ddc:570
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