publication . Doctoral thesis . 2011

Structural and quantitative characterisation of canine RAGE gene transcripts and evaluation of canine HMG genes and proteins for the establishment of therapeutic strategies

Sterenczak, Katharina;
Open Access English
  • Published: 01 Jan 2011
  • Country: Germany
Abstract
Cancer is the leading cause of death in economic strong countries and a large number of in vivo and in vitro models of human cancer were established until today. Thereby the dog has attracted scientific interest as neoplasias seen in dogs share many characteristics with their human counterparts. The aim of this thesis was the analysis of the molecular structure and/or expression pattern of cancer associated genes and proteins in canine neoplasias including the receptor RAGE and members of the HMG family. The results showed high similarities between the canine and human genes analysed and a valuable cell line based in vivo model of canine prostate cancer was esta...
Subjects
free text keywords: canine cancer, receptor RAGE, HMG family members, expression analyses, therapy, in vivo model prostate cancer, ddc:570
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