EGFR tyrosine kinase targeted compounds

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Gabr, Moustafa T.; El-Gohary, Nadia S.; El-Bendary, Eman R.; El-Kerdawy, Mohamed M.;
  • Subject: info:eu-repo/classification/ddc/610 | enzothiazoles | pyrimidobenzothiazoles | antitumor activity | EGFR tyrosine kinase inhibitory activity | molecular modeling

In this study, we illustrate computer aided drug design of new benzothiazole and pyrimido[2,1-b]benzothiazole derivatives as epidermal growth factor receptor tyrosine kinase (EGFR-TK) inhibitors. Compounds 1-5 were screened at NCI, USA, for antitumor activity against... View more
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