Spirooxindoles as novel 3D-fragment scaffolds: Synthesis and screening against CYP121 from $\textit{M. tuberculosis}$

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Davis, Holly J ; Kavanagh, Madeline ; Balan, Tudor ; Abell, Christopher ; Coyne, Anthony (2016)

The search for new scaffolds to complement current HTS and fragment libraries is an active area of research. The development of novel strategies to synthesise compounds with 3D character in order to expand the diversity of a fragment library was explored. A range of sub... View more
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