publication . Thesis . Other literature type . 2016

A novel polymeric prosthetic heart valve: design, manufacture, and testing

Brubert, Jacob;
English
  • Published: 01 Mar 2016
  • Publisher: University of Cambridge
  • Country: United Kingdom
Abstract
In this thesis a flexible leaflet polymeric prosthetic aortic heart valve was designed, manufactured, and tested. The prosthesis was designed with the aim of overcoming the need for anticoagulant therapy, which is required for current mechanical prostheses; while also having lifelong durability, which current bioprosthetic heart valves are not able to achieve. Inspired by the anisotropic architecture of collagen in the natural valve, a shortlist of polystyrene based block copolymers (BCPs), which can be processed to yield mechanically anisotropic materials, was proposed. The shortlist was evaluated based upon processability, biostability, ex vivo haemocompatibil...
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publication . Thesis . Other literature type . 2016

A novel polymeric prosthetic heart valve: design, manufacture, and testing

Brubert, Jacob;