A NOVEL PIPELINE FOR DRUG DISCOVERY IN NEUROPSYCHIATRIC DISORDERS USING HIGH-CONTENT SINGLE-CELL SCREENING OF SIGNALLING NETWORK RESPONSES EX VIVO

Doctoral thesis English OPEN
Lago Cooke, Santiago Guillermo;
(2016)
  • Publisher: Darwin
  • Related identifiers: doi: 10.17863/CAM.17148
  • Subject: drug discovery | neuropsychiatric disorders | high-content screening | single-cell | signalling network

The current work entails the development of a novel high content platform for the measurement of kinetic ligand responses across cell signalling networks at the single-cell level in distinct PBMC subtypes ex vivo. Using automated sample preparation, fluorescent cellular... View more
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