publication . Article . Other literature type . 2015

Functional Neuroimaging of Avoidance Habits in Obsessive-Compulsive Disorder

Gillan, Claire M.; Apergis-Schoute, Annemieke M.; Morein-Zamir, Sharon; Urcelay, Gonzalo P.; Sule, Akeem; Fineberg, Naomi A.; Sahakian, Barbara J.; Robbins, Trevor W.;
English
  • Published: 12 Jan 2015
  • Publisher: American Psychiatric Association
  • Country: United Kingdom
Abstract
Objective: The goal of this study was to determine the neural correlates of excessive habit formation in obsessive-compulsive disorder (OCD). We aimed to (i) test for neurobiological convergence with the known pathophysiology of OCD and (ii) infer, based on abnormalities in brain activation, whether these habits arise from dysfunction in the goal-directed or habit system. Method: Thirty-seven OCD patients and 33 controls learned to avoid shocks while undergoing a functional Magnetic Resonance Imaging (fMRI) scan. Following 4 blocks of training, we tested if the avoidance response had become a habit by removing the threat of shock and measuring continued avoidanc...
Subjects
Medical Subject Headings: humanities
free text keywords: Orbitofrontal cortex, Psychology, Neural correlates of consciousness, Brain activity and meditation, Prefrontal cortex, Avoidance response, Putamen, Clinical psychology, Psychiatry, medicine.medical_specialty, medicine, Functional neuroimaging, Caudate nucleus
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