publication . Other literature type . Article . 2019 . Embargo end date: 14 Aug 2019

Metabolic response to Parkinson's disease recapitulated by the haploinsufficient diploid yeast cells hemizygous for the adrenodoxin reductase gene

Dikicioglu, Duygu; Coxon, James W. M. T.; Oliver, Stephen G.;
  • Published: 14 Aug 2019
  • Publisher: Apollo - University of Cambridge Repository
  • Country: United Kingdom
Abstract
Adrenodoxin reductase, a widely conserved mitochondrial P450 protein, catalyses essential steps in steroid hormone biosynthesis and is highly expressed in the adrenal cortex. The yeast adrenodoxin reductase homolog, Arh1p, is involved in cytoplasmic and mitochondrial iron homeostasis and is required for activity of enzymes containing an Fe–S cluster. In this paper, we investigated the response of yeast to the loss of a single copy of , an oxidoreductase of the mitochondrial inner membrane, which is among the few mitochondrial proteins that is essential for viability in yeast. The phenotypic, transcriptional, proteomic, and metabolic landscape indicated that succ...
Subjects
free text keywords: Humans, Saccharomyces cerevisiae, Parkinson Disease, Ferredoxin-NADP Reductase, Iron-Sulfur Proteins, Saccharomyces cerevisiae Proteins, Membrane Proteins, Computational Biology, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Fungal, Ploidies, Mutation, Haploinsufficiency, Adrenodoxin reductase, Iron assimilation, Neurodegeneration, medicine.disease, medicine, Inner mitochondrial membrane, Oxidative phosphorylation, Yeast, biology.organism_classification, biology, Transcriptional regulation, Cell biology
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