publication . Other literature type . Article . 2018

Triazolophostins: a library of novel and potent agonists of IP3 receptors

Amol M. Vibhute; Vera Konieczny; Colin W. Taylor; Kana M. Sureshan;
  • Published: 13 Nov 2018
  • Country: United Kingdom
Abstract
IP R initiate most cellular Ca signaling. AdA is the most potent agonist of IP R. The structural complexity of AdA makes synthesis of its analogs cumbersome. We report an easy method for generating a library of potent triazole-based analogs of AdA, triazolophostins, which are the most potent AdA analogs devoid of a nucleobase.
Subjects
Medical Subject Headings: immune system diseaseshemic and immune systemsnutritional and metabolic diseasesenzymes and coenzymes (carbohydrates)congenital, hereditary, and neonatal diseases and abnormalities
ACM Computing Classification System: Data_CODINGANDINFORMATIONTHEORYSoftware_PROGRAMMINGLANGUAGES
free text keywords: Chemistry, Physical and Theoretical Chemistry, Organic Chemistry, Biochemistry, Anomer, Click chemistry, Adenosine, medicine.drug, medicine, Structure–activity relationship, Stereochemistry, Enzyme, chemistry.chemical_classification, Combinatorial chemistry, Agonist, medicine.drug_class, Receptor, Triazole, chemistry.chemical_compound
26 references, page 1 of 2

Berridge, M. J., Berridge, M. J., Lipp, P., Bootman, M. D., Guse, A. H.. Curr. Mol. Med.. 2004; 4: 239 [OpenAIRE] [PubMed] [DOI]

Nebel, M., Schwoerer, A. P., Warszta, D., Siebrands, C. C., Limbrock, A.-C., Swarbrick, J. M., Fliegert, R., Weber, K., Bruhn, S., Hohenegger, M., Geisler, A., Herich, L., Schlegel, S., Carrier, L., Eschenhagen, T., Potter, B. V. L., Ehmke, H., Guse, A. H., Guse, A. H., Galione, A., White, A., Hua, S.-Y., Tokimasa, T., Takasawa, S., Furuya, S., Nohmi, M., Okamoto, H., Kuba, K., Lee, H. C., Lukyanenko, V., Györke, I., Wiesner, T. F., Györke, S., Lee, H. C., Patel, S., Churchill, G. C., Galione, A., Seo, M.-D., Velamakanni, S., Ishiyama, N., Stathopulos, P. B., Rossi, A. M., Khan, S. A., Dale, P., Li, C., Ames, J. B., Ikura, M., Taylor, C. W.. Nature. 2012; 483: 108 [OpenAIRE] [PubMed]

Taylor, C. W., Tovey, S. C., Taylor, C. W., Genazzani, A. A., Morris, S. A.. Cell Calcium. 1999; 26: 237 [PubMed]

Mikoshiba, K., Taylor, C. W., Tovey, S. C., Saleem, H., Tovey, S. C., Rahman, T., Riley, A. M., Potter, B. V. L., Taylor, C. W., Foskett, J. K., White, C., Cheung, K. H., Mak, D. O., Rossi, A. M., Reley, A. M., Tovey, S. C., Rahman, T., Dellis, O., Taylor, E. J. A., Veresov, V. G., Potter, B. V. L., Taylor, C. W.. Nat. Chem. Biol.. 2009; 5: 631 [OpenAIRE] [PubMed]

Wundenberg, T., Mayr, G. W.. Biol. Chem.. 2012; 393: 979 [PubMed]

Potter, B. V. L., Lampe, D., Irvine, R. F., Schell, M. J., Best, M. D., Zhang, H., Prestwich, G. D.. Nat. Prod. Rep.. 2010; 27: 1403 [PubMed]

Capolicchio, S., Wang, H., Thakor, D. T., Shears, S. B., Jessen, H. J., Wu, M., Chong, L. S., Capolicchio, S., Jessen, H. J., Resnick, A. C., Fiedler, D., Capolicchio, S., Thakor, D. T., Linden, A., Jessen, H. J., Marmelstein, A. M., Yates, L. M., Conway, J. H., Fiedler, D., Wu, M., Dul, B. E., Trevisan, A. J., Fiedler, D.. Chem. Sci.. 2013; 4: 405 [OpenAIRE] [PubMed]

Takahashi, M., Kagasaki, T., Hosoya, T., Takahashi, S.. J. Antibiot.. 1993; 46: 1643 [PubMed]

Rossi, A. M., Riley, A. M., Potter, B. V. L., Taylor, C. W., Saleem, H., Tovey, S. C., Riley, A. M., Potter, B. V. L., Taylor, C. W., Borissow, C. N., Black, S. J., Paul, M., Tovey, S. C., Dedos, S. G., Taylor, C. W., Potter, B. V. L., Marchant, J. S., Beecroft, M. D., Riley, A. M., Jenkins, D. J., Marwood, R. D., Taylor, C. W., Potter, B. V. L., Shuto, S., Tatani, K., Ueno, Y., Matsuda, A., Marwood, R. D., Riley, A. M., Correa, V., Taylor, C. W., Potter, B. V. L., Hotoda, H., Murayama, K., Miyamoto, S., Iwata, Y., Takahashi, M., Kawase, Y., Tanzawa, K., Kaneko, M., Kashiwayanagi, M., Tatani, K., Shuto, S., Matsuda, A., Shuto, S., Terauchi, M., Yahiro, Y., Abe, H., Ichikawa, S., Matsuda, A., Chretien, F., Moitessier, N., Roussel, F., Mauger, J.-P., Chapleur, Y., Abe, H., Shuto, S., Matsuda, A., Mochizuki, T., Kondo, Y., Abe, H., Tovey, S. C., Dedos, S. G., Taylor, C. W., Paul, M., Potter, B. V. L., Matsuda, A., Shuto, S.. J. Med. Chem.. 2006; 49: 5750 [PubMed]

Bosanac, I., Alattia, J.-R., Mal, T. K., Chan, J., Talarico, S., Tong, F. K., Tong, K. I., Yoshikawa, F., Furuichi, T., Iwai, M., Michikawa, T., Mikoshiba, K., Ikura, M.. Nature. 2002; 420: 696 [OpenAIRE] [PubMed]

Correa, V., Riley, A. M., Shuto, S., Horne, G., Nerou, E. P., Marwood, R. D., Potter, B. V. L., Taylor, C. W.. Mol. Pharmacol.. 2001; 59: 1206 [PubMed]

Sureshan, K. M., Riley, A. M., Thomas, M. P., Tovey, S. C., Taylor, C. W., Potter, B. V. L., Sureshan, K. M., Trusselle, M., Tovey, S. C., Taylor, C. W., Potter, B. V. L., Rossi, A. M., Sureshan, K. M., Riley, A. M., Potter, B. V. L., Taylor, C. W.. Br. J. Pharmacol.. 2010; 161: 1070 [OpenAIRE] [PubMed]

Marwood, R. D., Shuto, S., Jenkins, D. J., Potter, B. V. L., Mochizuki, T., Kondo, Y., Abe, H., Taylor, C. W., Potter, B. V. L., Matsuda, A., Shuto, S.. Org. Lett.. 2006; 8: 1455 [PubMed]

Shuto, S., Horne, G., Marwood, R. D., Potter, B. V. L.. Chem. – Eur. J.. 2001; 7: 4937 [PubMed]

Koshkin, A. A., Fensholdt, J., Pfundheller, H. M., Lomholt, C., Robins, M. J., Zou, R., Guo, Z., Wnuk, S. F., Zhong, M., Robins, M. J.. Tetrahedron Lett.. 2003; 44: 9327 [PubMed]

26 references, page 1 of 2
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Other literature type . Article . 2018

Triazolophostins: a library of novel and potent agonists of IP3 receptors

Amol M. Vibhute; Vera Konieczny; Colin W. Taylor; Kana M. Sureshan;