publication . Article . Other literature type . 2017

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

Howson, Joanna; Zhao, W; Barnes, Daniel; Ho, W-K; Young, R; Paul, Dirk; Waite, LL; Freitag, DF; Fauman, EB; Salfati, EL; ...
Open Access English
  • Published: 25 Aug 2017
  • Publisher: Nature Publishing Group
  • Country: United Kingdom
Abstract
Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional susceptibility loci await identification. An efficient discovery strategy may be larger-scale evaluation of promising associations suggested by genome-wide association studies (GWAS). Hence, we genotyped 56,309 participants using a targeted gene array derived from earlier GWAS results and performed meta-analysis of results with 194,427 participants previously genotyped, totaling 88,192 CAD cases and 162,544 controls. We identified 25 new SNP-C...
Subjects
free text keywords: cardiovascular diseases, genome-wide association studies, Article
Funded by
NIH| Determinants of Insulin Mediated Glucose uptake in South Asians
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1K23DK088942-01A1
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
,
EC| EPICHEART
Project
EPICHEART
Interplay of genetic, nutrient and lifestyle factors on incidence of coronary disease: EPIC-Heart
  • Funder: European Commission (EC)
  • Project Code: 268834
  • Funding stream: FP7 | SP2 | ERC
,
EC| EPIC-CVD
Project
EPIC-CVD
EPIC-CVD: Individualised CVD risk assessment: tailoring targeted and cost-effective approaches to Europe's diverse populations
  • Funder: European Commission (EC)
  • Project Code: 279233
  • Funding stream: FP7 | SP1 | HEALTH
,
RCUK| Study of the interplay of genetic, biochemical, and lifestyle factors on coronary heart disease incidence
Project
  • Funder: Research Council UK (RCUK)
  • Project Code: G0800270
  • Funding stream: MRC
,
NIH| Trans-ethnic meta-analysis of blood pressure in African and European ancestries
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R21HL123677-02
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
Download fromView all 7 versions
Europe PubMed Central
Other literature type . 2017
UNC Dataverse
Other literature type . 2017
Provider: Datacite
23 references, page 1 of 2

Roth, G.A. et al. Demographic and epidemiologic drivers of global cardiovascular mortality. N Engl J Med 372, 1333-41 (2015).

G. B. D. Mortality & Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 385, 117-71 (2015).

CARDIoGRAMplusC4D Consortium et al. Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet 45, 25-33 (2013).

Myocardial Infarction Genetics Consortium et al. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet 41, 334-41 (2009).

IBC 50K CAD Consortium. Large-scale gene-centric analysis identifies novel variants for coronary artery disease. PLoS Genet 7, e1002260 (2011).

Samani, N.J. et al. Genomewide association analysis of coronary artery disease. N Engl J Med 357, 443-53 (2007).

Schunkert, H. et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet 43, 333-8 (2011). [OpenAIRE]

Erdmann, J. et al. New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet 41, 280-2 (2009).

CARDIoGRAMplusC4D Consortium. A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat Genet 47, 1121-30 (2015).

Voight, B.F. et al. The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet 8, e1002793 (2012).

Segre, A.V. et al. Pathways targeted by antidiabetes drugs are enriched for multiple genes associated with type 2 diabetes risk. Diabetes 64, 1470-83 (2015). [OpenAIRE]

GTEx Consortium. Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science 348, 648-60 (2015).

Grundberg, E. et al. Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet 44, 1084-9 (2012). [OpenAIRE]

Franzen, O. et al. Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases. Science 353, 827-30 (2016).

Ward, L.D. & Kellis, M. HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res 40, D930-4 (2012).

23 references, page 1 of 2
Abstract
Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional susceptibility loci await identification. An efficient discovery strategy may be larger-scale evaluation of promising associations suggested by genome-wide association studies (GWAS). Hence, we genotyped 56,309 participants using a targeted gene array derived from earlier GWAS results and performed meta-analysis of results with 194,427 participants previously genotyped, totaling 88,192 CAD cases and 162,544 controls. We identified 25 new SNP-C...
Subjects
free text keywords: cardiovascular diseases, genome-wide association studies, Article
Funded by
NIH| Determinants of Insulin Mediated Glucose uptake in South Asians
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1K23DK088942-01A1
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
,
EC| EPICHEART
Project
EPICHEART
Interplay of genetic, nutrient and lifestyle factors on incidence of coronary disease: EPIC-Heart
  • Funder: European Commission (EC)
  • Project Code: 268834
  • Funding stream: FP7 | SP2 | ERC
,
EC| EPIC-CVD
Project
EPIC-CVD
EPIC-CVD: Individualised CVD risk assessment: tailoring targeted and cost-effective approaches to Europe's diverse populations
  • Funder: European Commission (EC)
  • Project Code: 279233
  • Funding stream: FP7 | SP1 | HEALTH
,
RCUK| Study of the interplay of genetic, biochemical, and lifestyle factors on coronary heart disease incidence
Project
  • Funder: Research Council UK (RCUK)
  • Project Code: G0800270
  • Funding stream: MRC
,
NIH| Trans-ethnic meta-analysis of blood pressure in African and European ancestries
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R21HL123677-02
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
Download fromView all 7 versions
Europe PubMed Central
Other literature type . 2017
UNC Dataverse
Other literature type . 2017
Provider: Datacite
23 references, page 1 of 2

Roth, G.A. et al. Demographic and epidemiologic drivers of global cardiovascular mortality. N Engl J Med 372, 1333-41 (2015).

G. B. D. Mortality & Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 385, 117-71 (2015).

CARDIoGRAMplusC4D Consortium et al. Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet 45, 25-33 (2013).

Myocardial Infarction Genetics Consortium et al. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet 41, 334-41 (2009).

IBC 50K CAD Consortium. Large-scale gene-centric analysis identifies novel variants for coronary artery disease. PLoS Genet 7, e1002260 (2011).

Samani, N.J. et al. Genomewide association analysis of coronary artery disease. N Engl J Med 357, 443-53 (2007).

Schunkert, H. et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet 43, 333-8 (2011). [OpenAIRE]

Erdmann, J. et al. New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet 41, 280-2 (2009).

CARDIoGRAMplusC4D Consortium. A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat Genet 47, 1121-30 (2015).

Voight, B.F. et al. The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet 8, e1002793 (2012).

Segre, A.V. et al. Pathways targeted by antidiabetes drugs are enriched for multiple genes associated with type 2 diabetes risk. Diabetes 64, 1470-83 (2015). [OpenAIRE]

GTEx Consortium. Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science 348, 648-60 (2015).

Grundberg, E. et al. Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet 44, 1084-9 (2012). [OpenAIRE]

Franzen, O. et al. Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases. Science 353, 827-30 (2016).

Ward, L.D. & Kellis, M. HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res 40, D930-4 (2012).

23 references, page 1 of 2
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . Other literature type . 2017

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

Howson, Joanna; Zhao, W; Barnes, Daniel; Ho, W-K; Young, R; Paul, Dirk; Waite, LL; Freitag, DF; Fauman, EB; Salfati, EL; ...