publication . Other literature type . Article . 2016 . Embargo end date: 29 Jun 2016

Advancing haematopoietic stem and progenitor cell biology through single-cell profiling

Hamey, Fiona; Shaw, Sonia; Wilson, Nicola; Gottgens, Berthold;
English
  • Published: 21 Jun 2016
  • Publisher: Apollo - University of Cambridge Repository
  • Country: United Kingdom
Abstract
Haematopoietic stem and progenitor cells (HSPCs) sit at the top of the haematopoietic hierarchy, and their fate choices need to be carefully controlled to ensure balanced production of all mature blood cell types. As cell fate decisions are made at the level of the individual cells, recent technological advances in measuring gene and protein expression in increasingly large numbers of single cells have been rapidly adopted to study both normal and pathological HSPC function. In this review we emphasise the importance of combining the correct computational models with single-cell experimental techniques, and illustrate how such integrated approaches have been use...
Subjects
free text keywords: computational models, fate choice, haematopoietic stem/progenitor cells, heterogeneity, lineage differentiation, single-cell
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publication . Other literature type . Article . 2016 . Embargo end date: 29 Jun 2016

Advancing haematopoietic stem and progenitor cell biology through single-cell profiling

Hamey, Fiona; Shaw, Sonia; Wilson, Nicola; Gottgens, Berthold;