Naked mole-rat cortical neurons are resistant to acid-induced cell death

Article English OPEN
Husson, Zoé ; Smith, Ewan St. John (2018)
  • Publisher: BioMed Central
  • Journal: Molecular Brain, volume 11 (issn: 1756-6606, eissn: 1756-6606)
  • Related identifiers: doi: 10.17863/CAM.22885, doi: 10.1186/s13041-018-0369-4, doi: 10.17863/CAM.27750, pmc: PMC5941639
  • Subject: ASIC | Acid-induced currents | Neurology. Diseases of the nervous system | Cell Death | Acid Sensing Ion Channels | Hippocampus | RC346-429 | Magnetic Resonance Spectroscopy | Mole Rats | Neurons | Ion Channel Gating | Research | Acidotoxicity | Cerebral Cortex | Naked mole-rat | Sodium Channels | Hydrogen-Ion Concentration | Animals

Abstract Regulation of brain pH is a critical homeostatic process and changes in brain pH modulate various ion channels and receptors and thus neuronal excitability. Tissue acidosis, resulting from hypoxia or hypercapnia, can activate various proteins a... View more
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