Naked mole-rat cortical neurons are resistant to acid-induced cell death
Smith, Ewan St. John
- Publisher: BioMed Central
(issn: 1756-6606, eissn: 1756-6606)
ASIC | Acid-induced currents | Neurology. Diseases of the nervous system | Cell Death | Acid Sensing Ion Channels | Hippocampus | RC346-429 | Magnetic Resonance Spectroscopy | Mole Rats | Neurons | Ion Channel Gating | Research | Acidotoxicity | Cerebral Cortex | Naked mole-rat | Sodium Channels | Hydrogen-Ion Concentration | Animals
Regulation of brain pH is a critical homeostatic process and changes in brain pH modulate various ion channels and receptors and thus neuronal excitability. Tissue acidosis, resulting from hypoxia or hypercapnia, can activate various proteins a...