publication . Article . 2015

Intracellular localization and dynamics of Hypericin loaded PLLA nanocarriers by image correlation spectroscopy

Rozhin Penjweini; Sarah Deville; Lien D'Olieslaeger; Mandy Berden; Marcel Ameloot; Anitha Ethirajan;
Open Access English
  • Published: 01 Jan 2015
  • Publisher: ELSEVIER SCIENCE BV
  • Country: Belgium
Abstract
The study of cell-nanoparticle interactions is an important aspect for understanding drug delivery using nanocarriers. In this regard, advances in fluorescence based microscopy are useful for the investigation of temporal and spatial behavior of nanoparticles (NPs) within the intracellular environment. In this work, we focus on the delivery of the naturally-occurring hydrophobic photosensitizer Hypericin in human lung carcinoma A549 cells by using biodegradable poly L-lactic acid NPs. For the first time, Hypericin containing NPs are prepared by combining the miniemulsion technique with the solvent evaporation method. This approach yields an efficient loading of ...
Subjects
Medical Subject Headings: technology, industry, and agriculturerespiratory systemmental disordersinorganic chemicals
free text keywords: PLLA nanoparticles; Hypericin; Miniemulsion; STICS; TICS; STICCS, Pharmaceutical Science, Hypericin, chemistry.chemical_compound, chemistry, Miniemulsion, Photosensitizer, Nanoparticle, Drug delivery, Organic chemistry, Drug carrier, Nanocarriers, Fluorescence, Nanotechnology
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publication . Article . 2015

Intracellular localization and dynamics of Hypericin loaded PLLA nanocarriers by image correlation spectroscopy

Rozhin Penjweini; Sarah Deville; Lien D'Olieslaeger; Mandy Berden; Marcel Ameloot; Anitha Ethirajan;