publication . Article . 2018

Apoptotic-induced effects of Castanea sativa Mill. bark extract in human SH-SY5Y neuroblastoma

Santulli, C.; Brizi, C.; Micucci, M.; Budriesi, R.; Chiarini, A.; Frosini, M.;
Open Access English
  • Published: 01 Jan 2018
  • Country: Italy
Castanea sativa Mill. wood extract (ENC) has health-promoting qualities such as antibacterial, antiviral, antispasmodic, cardio- and neuroprotective-activities. Its potential towards cancer cells of the central nervous system, however, is still unexplored. This study investigates the apoptotic-enhancing effect of ENC in human neuroblastoma SH-SY5Y cell line. This extract irreversibly decreased cell viability with IC50 of 142.8±20.2, 109.3±16.6 and 82.5±8.6 μg/mL for 24h, 48 and 72h of treatment, respectively. This was accompanied by cell shrinkage and tendency to round-up. A concentration-dependent increase in sub G0/G1 cells as well as a rise in cells with nucl...
free text keywords: Castanea sativa, Apoptosis, Neuroblastoma, SH-SY5Y cells, Tannins, Vescalagin, Castalagin, Ellagic acid.
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