publication . Article . Other literature type . 2012

Genome-wide CpG island methylation analysis implicates novel genes in the pathogenesis of renal cell carcinoma.

Ricketts, Christopher J.; Morris, Mark R.; Gentle, Dean; Brown, Michael; Wake, Naomi; Woodward, Emma R.; Clarke, Noel; Latif, Farida; Maher, Eamonn R.;
Open Access English
  • Published: 01 Mar 2012
  • Country: New Zealand
Abstract
In order to identify novel candidate tumor suppressor genes (TSGs) implicated in renal cell carcinoma (RCC), we performed genome-wide methylation profiling of RCC using the HumanMethylation27 BeadChips to assess methylation at >14,000 genes. Two hundred and twenty hypermethylated probes representing 205 loci/genes were identified in genomic CpG islands. A subset of TSGs investigated in detail exhibited frequent tumor methylation, promoter methylation associated transcriptional silencing and reactivation after demethylation in RCC cell lines and downregulation of expression in tumor tissue (e.g., SLC34A2 specifically methylated in 63% of RCC, OVOL1 in 40%, DLE...
Subjects
Medical Subject Headings: urologic and male genital diseases
free text keywords: Epigenetics, Methylation, Renal cell carcinoma (RCC), /dk/atira/pure/subjectarea/asjc/1300/1312, Molecular Biology, /dk/atira/pure/subjectarea/asjc/1300/1306, Cancer Research, Renal Cancer, RCC, Research Paper, DNA methylation, Gene, RNA interference, Gene silencing, CpG site, Cancer, medicine.disease, medicine, Genetics, Biology
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publication . Article . Other literature type . 2012

Genome-wide CpG island methylation analysis implicates novel genes in the pathogenesis of renal cell carcinoma.

Ricketts, Christopher J.; Morris, Mark R.; Gentle, Dean; Brown, Michael; Wake, Naomi; Woodward, Emma R.; Clarke, Noel; Latif, Farida; Maher, Eamonn R.;