publication . Article . Other literature type . 2007

Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development

Dagan Jenkins; Paul J. D. Winyard; Adrian S. Woolf;
Open Access English
  • Published: 01 Nov 2007
  • Country: Switzerland
Abstract
Studies of mouse mutants have demonstrated that Sonic hedgehog (SHH) signalling has a functional role in morphogenesis and differentiation at multiple sites within the forming urinary tract, and urinary tract malformations have been reported in humans with mutations that disrupt SHH signalling. However, there is only strikingly sparse and fragmentary information about the expression of SHH and associated signalling genes in normal human urinary tract development. We used immunohistochemistry to demonstrate that SHH protein was localised in distinct urinary tract epithelia in developing normal humans, in the urothelium of the nascent bladder and in kidney medulla...
Subjects
Medical Subject Headings: embryonic structuresanimal structures
free text keywords: Bladder, Collecting duct, Smooth muscle, Uroplakin, Urothelium, /dk/atira/pure/subjectarea/asjc/1100/1101, Agricultural and Biological Sciences (miscellaneous), /dk/atira/pure/subjectarea/asjc/2700/2702, Anatomy, Original Articles, Morphogenesis, Sonic hedgehog, biology.protein, biology, Bone morphogenetic protein 4, Smoothened, Paracrine signalling, Patched Receptors, Patched
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