BeWo cells stimulate smooth muscle cell apoptosis and elastin breakdown in a model of spiral artery transformation

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Harris, L. K.; Keogh, R. J.; Wareing, M.; Baker, P. N.; Cartwright, J. E.; Whitley, G. S.; Aplin, J. D.;
  • Related identifiers: doi: 10.1093/humrep/dem303
  • Subject: Developmental Biology | Physiology | Apoptosis | Fas ligand | /dk/atira/pure/subjectarea/asjc/2700/2729 | Vascular remodelling | Obstetrics and Gynaecology | Matrix metalloproteinase | /dk/atira/pure/subjectarea/asjc/1300/1314 | Reproductive Medicine | Trophoblast invasion | /dk/atira/pure/subjectarea/asjc/1300/1309 | /dk/atira/pure/subjectarea/asjc/2700/2743
    mesheuropmc: cardiovascular system | embryonic structures

BACKGROUND: During pregnancy, extravillous trophoblast invades the uterine wall and enters the spiral arteries. Remodelling ensues, with loss of vascular smooth muscle cells (SMCs) to create high flow, low resistance vessels. Pregnancies complicated by pre-eclampsia are... View more
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