publication . Article . 2007

BeWo cells stimulate smooth muscle cell apoptosis and elastin breakdown in a model of spiral artery transformation

John Aplin; Mark Wareing; Judith Cartwright; Guy Whitley; Philip Baker; Lynda K Harris;
Open Access English
  • Published: 27 Sep 2007
  • Country: United Kingdom
Abstract
BACKGROUND: During pregnancy, extravillous trophoblast invades the uterine wall and enters the spiral arteries. Remodelling ensues, with loss of vascular smooth muscle cells (SMCs) to create high flow, low resistance vessels. Pregnancies complicated by pre-eclampsia are characterized by incomplete arterial remodelling. Endovascular trophoblast is not easily accessible for studies to establish the pathogenesis of pre-eclampsia, so we have developed a model appropriate to carry out mechanistic studies of vessel wall transformation. METHODS AND RESULTS: Segments of human spiral artery were perfused with the choriocarcinoma cell line, BeWo; cells invaded the vessel ...
Subjects
Medical Subject Headings: embryonic structurescardiovascular system
free text keywords: Apoptosis, Fas ligand, Matrix metalloproteinase, Trophoblast invasion, Vascular remodelling, /dk/atira/pure/subjectarea/asjc/1300/1314, Physiology, /dk/atira/pure/subjectarea/asjc/1300/1309, Developmental Biology, /dk/atira/pure/subjectarea/asjc/2700/2729, Obstetrics and Gynaecology, /dk/atira/pure/subjectarea/asjc/2700/2743, Reproductive Medicine
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