publication . Article . Review . 2012

STN DBS causes mix of output responses

Humphries, Mark D; Gurney, Kevin;
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  • Published: 01 Jul 2012 Journal: European Journal of Neuroscience, volume 36, pages 2,240-2,251 (issn: 0953-816X, Copyright policy)
  • Publisher: Wiley
  • Country: Switzerland
Abstract
Deep brain stimulation (DBS) is a remarkably successful treatment for the motor symptoms of Parkinson's disease. High-frequency stimulation of the subthalamic nucleus (STN) within the basal ganglia is a main clinical target, but the physiological mechanisms of therapeutic STN DBS at the cellular and network level are unclear. We set out to begin to address the hypothesis that a mixture of responses in the basal ganglia output nuclei, combining regularized firing and inhibition, is a key contributor to the effectiveness of STN DBS. We used our computational model of the complete basal ganglia circuit to show how such a mixture of responses in basal ganglia output...
Subjects
Medical Subject Headings: nervous systemsurgical procedures, operativenervous system diseasestherapeutics
free text keywords: High-frequency stimulation, /dk/atira/pure/subjectarea/asjc/2800, Neuroscience(all), General Neuroscience, Parkinson's disease, medicine.disease, medicine, Deep brain stimulation, medicine.medical_treatment, Optogenetics, Neuroscience, Basal ganglia, Network level, Subthalamic nucleus, Stimulation, Biology
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publication . Article . Review . 2012

STN DBS causes mix of output responses

Humphries, Mark D; Gurney, Kevin;