publication . Article . 2014

Continuous flow chemistry: a discovery tool for new chemical reactivity patterns

Jan Hartwig; Jan B. Metternich; Nikzad Nikbin; Andreas Kirschning; Steven V. Ley;
Open Access
  • Published: 17 Apr 2014 Journal: Org. Biomol. Chem., volume 12, pages 3,611-3,615 (issn: 1477-0520, eissn: 1477-0539, Copyright policy)
  • Publisher: Royal Society of Chemistry (RSC)
  • Country: Germany
Abstract
Continuous flow chemistry as a process intensification tool is well known. However, its ability to enable chemists to perform reactions which are not possible in batch is less well studied or understood. Here we present an example, where a new reactivity pattern and extended reaction scope has been achieved by transferring a reaction from batch mode to flow. This new reactivity can be explained by suppressing back mixing and precise control of temperature in a flow reactor set up. EPSRC/EP/F069685/1 EPSRC/ EP/F069685/1 Fonds der Chemischen Industrie
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Subjects
free text keywords: Physical and Theoretical Chemistry, Organic Chemistry, Biochemistry, Organic-Synthesis, Enabling Technology, Multistep Synthesis, Reactors, Microreactors, Ketones, Batch, Combinatorial chemistry, Magnetic nanoparticles, Batch processing, Flow chemistry, Chemistry, Microreactor, Flow (psychology), Chemical engineering, Reactivity (chemistry), Continuous flow, Organic synthesis, chemistry.chemical_compound, ddc:540
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