publication . Article . Other literature type . 2016

Inhibition of alpha oscillations through serotonin-2A receptor activation underlies the visual effects of ayahuasca in humans

Marta Valle; Ana Elda Maqueda; Mireia Rabella; Aina Rodríguez-Pujadas; Rosa M. Antonijoan; Sergio Romero; Joan Francesc Alonso; Miquel Àngel Mañanas; Steven A. Barker; Pablo Friedlander; ...
Open Access
  • Published: 01 Jul 2016 Journal: European Neuropsychopharmacology, volume 26, pages 1,161-1,175 (issn: 0924-977X, Copyright policy)
  • Publisher: Elsevier BV
  • Country: Spain
Abstract Ayahuasca is an Amazonian psychotropic plant tea typically obtained from two plants, Banisteriopsis caapi and Psychotria viridis . It contains the psychedelic 5-HT 2A and sigma-1 agonist N , N -dimethyltryptamine (DMT) plus β-carboline alkaloids with monoamine-oxidase (MAO)-inhibiting properties. Although the psychoactive effects of ayahuasca have commonly been attributed solely to agonism at the 5-HT 2A receptor, the molecular target of classical psychedelics, this has not been tested experimentally. Here we wished to study the contribution of the 5-HT 2A receptor to the neurophysiological and psychological effects of ayahuasca in humans. We measured d...
Persistent Identifiers
free text keywords: Pharmacology (medical), Biological Psychiatry, Pharmacology, Neurology, Psychiatry and Mental health, Clinical Neurology, :Ciències de la salut::Medicina [Àrees temàtiques de la UPC], Ayahuasca., Serotonin-2A receptor, Subjective effects, Neurophysiological effects, Human, Drogues, Serotonin, Dimethyltryptamine, Psychology, Agonist, medicine.drug_class, medicine, Antagonist, Banisteriopsis caapi, biology.organism_classification, biology, Ketanserin, medicine.drug, Psychotria viridis, Ayahuasca
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