publication . Doctoral thesis . 2015

A computational study of intervertebral disc degeneration in relation to changes in regional tissue composition and disc nutrition

Ruiz Wills, Carlos;
Open Access English
  • Published: 17 Jul 2015
  • Publisher: Universitat Politècnica de Catalunya
  • Country: Spain
Abstract
Up to 85% of the world population suffers from low back pain, a clinical condition often related to the intervertebral disc (IVD) degeneration (DD). Altered disc cell nutrition affects cell viability and can generate catabolic cascades that degrade the extracellular matrix (ECM). Also, a major degenerative biochemical change in the disc is the proteoglycan (PG) loss, which affects the osmotic pressure and hydration that is critical for cell nutrition. However, the relationship between biochemical degradation and nutrition along degeneration is unclear. The effect of cartilage endplates (CEP) tissue changes through known composition data remains unknown as well. ...
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Subjects
free text keywords: :Enginyeria dels materials [Àrees temàtiques de la UPC], 004, 615, 616.7
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