publication . Article . 2000

Direct n.c.a. radioiodination of weakly activated arenes using metal salts

E. Mennicke; M.H. Holschbach; Heinz H. Coenen;
Open Access English
  • Published: 01 Jan 2000
  • Publisher: Oldenbourg
  • Country: Germany
Abstract
The direct electrophilic no-carrier-added (n.c.a.) aromatic radioiodination was examined using various metal salts in trifluoroacetic acid (TFA) as in situ oxidation agents. Two different types of metal salts were used comprising TFA-soluble (Pb(CH3CO2)(4), Mn(CH3CO2)(3), KMnO4, Tl(CF3CO2)(3), AgCF3SO3) and TFA-insoluble (Ce(CF3SO3)(4), RuCl3, FeBr3, K2Cr2O7) salts. Optimization of both labelling systems has been performed using Pb(CH3CO2)(4), Ce(CF3SO3)(4) and benzene as a model substrate. At room temperature, the one-pot synthesis was completed within 15 min, resulting in a radiochemical yield of 82% and 64% using Pb(CH3CO2)(4) and Ce(CF3SO3)(4), respectively....
Subjects
free text keywords: J, direct radioiodination, n.c.a. labelling, electrophilic substitution, weakly activated arenes, metal salts, trifluoroacetyl hypoiodite, ddc:540, Physical and Theoretical Chemistry, Chlorobenzene, chemistry.chemical_compound, chemistry, Reaction mechanism, Trifluoroacetic acid, Benzene, Electrophile, Inorganic chemistry, Nuclear chemistry, Manganese, chemistry.chemical_element, Toluene
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publication . Article . 2000

Direct n.c.a. radioiodination of weakly activated arenes using metal salts

E. Mennicke; M.H. Holschbach; Heinz H. Coenen;