publication . Article . 2017

Tartrazine induced changes in physiological and biochemical parameters in Swiss albino mice, Mus musculus

Arefin, Sayema; Hossain, Mohammad Salim; Akter Neshe, Shamme; Rashid, Md. Mamun Or; Amin, Mohammad Tohidul; Hussain, Md. Saddam;
Open Access English
  • Published: 01 Jan 2017
  • Country: Turkey
Abstract
Now-a-days synthetic food dyes are being used most commonly as food colorant in confectionaries, drugs and cosmetics. Present study was designed to evaluate the toxic effect of tartrazine, a widely used azo dye, on Swiss Albino mice. Experimental animals were treated with tested dye at a dose level 200mg/kg & 400mg/kg body weight along with normal diet. Various physiological and biochemical parameters were assessed to study the toxic effect of tartrazine. Our study revealed a highly noticeable decrease in the body weight gain of mice at 400mg/kg dose compared with the control group. A significant variation in the average weight of the major organs (heart, kidney...
Subjects
free text keywords: Azo-Dye, tartrazine, Swiss Albino Mice, Physiological changes, Serum biochemistry
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