publication . Article . 2014

Acute liver allograft antibody-mediated rejection:an inter-institutional study of significant histopathological features

Jacqueline G. O'Leary; S. Michelle Shiller; Christopher Bellamy; Michael A. Nalesnik; Hugo Kaneku; Linda W. Jennings; Kumiko Isse; Paul I. Terasaki; Goran B. Klintmalm; Anthony J. Demetris;
Open Access English
  • Published: 01 Oct 2014
  • Country: United Kingdom
Abstract
<p>Acute antibody-mediated rejection (AMR) occurs in a small minority of sensitized liver transplant recipients. Although histopathologic characteristics have been described, specific features that could be used: a) for a generalizable scoring system; and b) to trigger a more in-depth analysis are needed to screen for this rare but important finding. Toward this goal, we created a training and validation cohort from 3 high volume liver transplant programs of putative acute AMR and control cases that were evaluated blindly by 4 independent transplant pathologists. Evaluations were performed on H&amp;E sections alone without knowledge of either serum DSA results o...
Subjects
free text keywords: Hepatology, Surgery, Transplantation, Liver transplantation, medicine.medical_treatment, medicine, Retrospective cohort study, Isoantibodies, Antibody mediated rejection, Scoring system, Pathology, medicine.medical_specialty, Biopsy, medicine.diagnostic_test, business.industry, business, Human leukocyte antigen, H&E stain
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