publication . Article . Other literature type . 2018

Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Pirro G. Hysi; Margaret A. Pericak-Vance; Ching-Yu Cheng; Ching-Yu Cheng; Gadi Wollstein; René Höhn; René Höhn; Chris C. A. Spencer; Tanja Zeller; Yih-Chung Tham; ...
Open Access English
  • Published: 14 May 2018 Journal: Nature Communications, volume 9, issue 1 (issn: 20411723, Copyright policy)
Abstract
Reduced central corneal thickness (CCT) is observed in common eye diseases as well as in rare Mendelian disorders. Here, in a cross-ancestry GWAS, the authors identify 19 novel genetic loci associated with CCT, a subset of which is involved in rare corneal or connective tissue disorders.
Subjects
Medical Subject Headings: genetic structureseye diseasessense organs
free text keywords: General Biochemistry, Genetics and Molecular Biology, General Physics and Astronomy, General Chemistry, 610 Medicine & health, 610 Medicine & health, Article, Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, OPEN-ANGLE GLAUCOMA, STROMAL DYSTROPHY, CHROMATIN STATES, GENE-EXPRESSION, MARFAN-SYNDROME, DECORIN GENE, RISK-FACTOR, TWIN EYE, KERATOCONUS, MUTATIONS, Science, Q, Mendelian Randomization Analysis, Genetics, Genome-wide association study, Candidate gene, Cornea, medicine.anatomical_structure, medicine, Corneal Diseases, Glaucoma, medicine.disease, Quantitative trait locus, Keratoconus, Biology
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