Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

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Iglesias, Adriana I; Vitart, Veronique; Li, Xiaohui; Yazar, Seyhan; Nag, Abhishek; Khawaja, Anthony P.; Polasek, Ozren; Siscovick, David; Mitchell, Paul; Chung Tham, Yih; Haines, Jonathan L; Kearns, Lisa S; Hayward, Caroline; Shi, Yuan; van Leeuwen, Elisabeth M; Taylor, Kent D; Bonnemaijer, Pieter; Rotter, Jerome I; Martin, Nick G; Zeller, Tanja; Mills, Richard A; Staffieri, Sandra E; Jonas, Jost; Schmidtmann, Irene; Boutin, Thibaud; Kang, Jae Hee; Wong, Tien Yin; Beutel, M.E; Uitterlinden, Andre; Lucas, Sionne E M; ... view all 41 authors

Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. Pathway analyses uncover new, as well as supported... View more
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