publication . Article . Other literature type . 1999

The inhibition of NF-kappaB activation pathways and the induction of apoptosis by dithiocarbamates in T cells are blocked by the glutathione precursor N-acetyl-L-cysteine

Heussler, Volker; Machado, J; Fernandez, P C; Palmer, G H; Dobbelaere, D A; Botteron, C;
Open Access English
  • Published: 20 Jan 1999
  • Publisher: De Gruyter
  • Country: Switzerland
Abstract
Nuclear factor-kappaB regulates genes that control immune and inflammatory responses and are involved in the pathogenesis of several diseases, including AIDS and cancer. It has been proposed that reactive oxygen intermediates participate in NF-kappaB activation pathways, and compounds with putative antioxidant activity such as N-acetyl-L-cysteine (NAC) and pyrrolidine dithiocarbamate (PDTC) have been used interchangeably to demonstrate this point. We examined their effects, separately and combined, on different stages of the NF-kappaB activation pathway, in primary and in transformed T cells. We show that NAC, contrary to its reported role as an NF-kappaB inhibi...
Subjects
free text keywords: 570 Life sciences; biology, Clinical Biochemistry, Biochemistry, Molecular Biology, Pyrrolidine dithiocarbamate, chemistry.chemical_compound, chemistry, Reporter gene, Apoptosis, p38 mitogen-activated protein kinases, Biology, Kinase, Immune system, Glutathione, Antioxidant, medicine.medical_treatment, medicine
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publication . Article . Other literature type . 1999

The inhibition of NF-kappaB activation pathways and the induction of apoptosis by dithiocarbamates in T cells are blocked by the glutathione precursor N-acetyl-L-cysteine

Heussler, Volker; Machado, J; Fernandez, P C; Palmer, G H; Dobbelaere, D A; Botteron, C;