publication . Article . 2011

Pharmacokinetics and pharmacodynamics of antibacterial agents: on account of febrile neutropenic patients

Javier R Garzón; Sonia Cuervo M; Julio Gómez R; Jorge A Cortés;
Open Access Spanish
  • Published: 01 Dec 2011
  • Publisher: Sociedad Chilena de Infectología
Abstract
Resumen La neutropenia febril es una complicacion grave de la terapia antineoplasica que se presenta mas frecuentemente en pacientes con neoplasias hematologicas, asociada a tasas elevadas de mortalidad. Uno de los factores des-critos como causa de fracasos terapeuticos de la terapia antimicrobiana es la inadecuada concentracion tisular de los antimicrobianos que a su vez se correlaciona con bajas concentraciones en el liquido intersticial en el caso de los farmacos hidrofilicos. En pacientes criticamente enfermos se puede presentar acumulacion compartimental de liquidos que a su vez se puede asociar con aumento en el volumen de distribucion de los medicamentos ...
Subjects
free text keywords: Agentes antibacterianos, administración & dosificación, uso terapéutico, terapéutica, fiebre, etiología, terapia, humanos, neoplasias hematológicas, complicaciones, neutropenia, terapia, Anti-infective agents, administration & dosage, therapeutic use, drug therapy, standards, fever, drug therapy, etiology, humans, hematologic neoplasms, complications, neutropenia, etiology, administración & dosificación, Public Health, Environmental and Occupational Health, Infectious Diseases, Febrile neutropenia, medicine.disease, medicine, business.industry, business, Gynecology, medicine.medical_specialty, Virology, Neutropenia, Antibiotic therapy, Cancer, INT, Surgery, Current spectrum, Interventional therapy, Chilena, biology.organism_classification, biology
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publication . Article . 2011

Pharmacokinetics and pharmacodynamics of antibacterial agents: on account of febrile neutropenic patients

Javier R Garzón; Sonia Cuervo M; Julio Gómez R; Jorge A Cortés;