publication . Other literature type . Article . 2011

Snake population venomics and antivenomics of Bothrops atrox: Paedomorphism along its transamazonian dispersal and implications of geographic venom variability on snakebite management

Ana M. Moura-da-Silva; Alicia Pérez; Juan J. Calvete; José María Gutiérrez; Rosa Helena Veras Mourão; Hipócrates M. Chalkidis; Yamileth Angulo; Alba M. Vargas; Bruno Lomonte; Libia Sanz; ...
Open Access
  • Published: 11 Apr 2011
  • Publisher: Elsevier BV
  • Country: Costa Rica
Abstract
We describe two geographically differentiated venom phenotypes across the wide distribution range of Bothrops atrox, from the Colombian Magdalena Medio Valley through Puerto Ayacucho and El Paují, in the Venezuelan States of Amazonas and Orinoquia, respectively, and São Bento in the Brazilian State of Maranhão. Colombian and Venezuelan venoms show an ontogenetic toxin profile phenotype whereas Brazilian venoms exhibit paedomorphic phenotypes. Venoms from each of the 16 localities sampled contain both population-specific toxins and proteins shared by neighboring B. atrox populations. Mapping the molecular similarity between conspecific populations onto a physical...
Subjects
free text keywords: Biophysics, Biochemistry, Bothrops atrox, Snake venom proteomics, Snake population venomics, Geographic venom variability, Paedomorpohism, N-terminal sequence, Mass spectrometry, Envenomation, Amazon rainforest, Biological dispersal, Bothrops, biology.organism_classification, biology, Population, education.field_of_study, education, Ecology, Poison control, Allopatric speciation, Antivenom
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