publication . Article . 2016

Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis

Elizabeth García; María V Bianco; Federico C Blanco; Fabiana Bigi;
Open Access English
  • Published: 31 Aug 2016
Abstract
Here we confirm the efficacy of MbΔmce2-phoP to protect mice against bTB challenge and we demonstrated that this new attenuated strain is safer than our previous bTB vaccine MbΔmce2. Altogether these results support the further assessment of this candidate in cattle model of bTB.Experiments with mice were performed in compliance with the regulations of the Institutional Animal Care and Use Committee (CICUAE) of INTA (61/2014).. Inst. de Biotecnología Fil: Garcia, Elizabeth Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina Fil: Bianco, Marí­a Veronica. Instituto Nacional de Tecnología Agropecuaria...
Subjects
free text keywords: Enfermedades de los Animales, Mycobacterium Bovis, Tuberculosis, Infección por Mycobacterium Bovis, Animal Diseases, Mycobacterium Bovis Infections, Microbiology, Parasitology, Virology, Infectious Diseases, General Medicine, Bacterial protein, Attenuated vaccine, C57BL/6, biology.organism_classification, biology, Gene deletion, Tuberculosis vaccines, Locus (genetics), medicine.disease, medicine, business.industry, business
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publication . Article . 2016

Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis

Elizabeth García; María V Bianco; Federico C Blanco; Fabiana Bigi;