publication . Doctoral thesis . 2014

Aceturato de diminazeno lipossomal no tratamento da infecção porTrypanosoma evansi: testes in vitro e in vivo

Oliveira, Camila Belmonte;
Open Access Portuguese
  • Published: 02 Jul 2014
  • Publisher: Universidade Federal de Santa Maria
Abstract
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior The aim of this study was to develop and to evaluate the therapeutic efficacy of liposomes diminazene aceturate and in vitro and by using mice experimentally infected with Trypanosoma evansi. In vitro tests were performed in culture medium at concentrations of 0.25, 0.5, 1, 2 and 3 mg/ml of diminazene aceturate convetional (CDMZ) and liposomal (L-DMZ). A total of 114 rats (Rattus norvegicus) were used of in vivo test. These rats were divided into 6 groups (A, B, C, D, E and F). Group A served as a negative control (uninfected and untreated). Rats in Group B served as a positive control and were infected...
Subjects
free text keywords: Nanoestruturas, Tripanossomoses, Diamidinas, Nanostructures, Diamidines, :CIENCIAS AGRARIAS::MEDICINA VETERINARIA [CNPQ]
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