publication . Article . 1991

Neutralization of coral snake Micrurus nigrocinctus venom by a monovalent antivenom

Gutierrez, J. M.; Rojas, G.; Perez, A.; Arguello, I.; Bruno Lomonte;
  • Published: 01 Jan 1991
  • Country: Costa Rica
Abstract
The neutralizing ability of a monovalent anti-Micrurus nigrocinctus (coral snake) antivenom produced in Costa Rica was tested against the lethal, myotoxic and phospholipase A2 activities of homologous venom. In addition, immunodiffusion and Western blot analyses were performed. 2. In experiments where venom and antivenom were incubated prior to the test, antivenom was effective in neutralizing lethal, myotoxic and phospholipase A2 activities, with Effective Doses 50% of 2700 microliters antivenom/mg venom, 1840 microliters antivenom/mg venom, and 3630 microliters antivenom/mg venom, respectively. 3. When coral snake antivenom was administered at different times ...
Subjects
Medical Subject Headings: complex mixtures
free text keywords: Animals, Antivenins, Blotting, Western, Elapid Venoms, Immunodiffusion, Lethal Dose 50, Mice, Phospholipases A, Phospholipases A2, Species Specificity, Snake venom
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publication . Article . 1991

Neutralization of coral snake Micrurus nigrocinctus venom by a monovalent antivenom

Gutierrez, J. M.; Rojas, G.; Perez, A.; Arguello, I.; Bruno Lomonte;