publication . Article . 1987

Skeletal muscle necrosis induced by a phospholipase A2 isolated from the venom of the coral snake Micrurus nigrocinctus nigrocinctus

Olga Arroyo; Jean Pierre Rosso; Orietta Vargas; JoséMaría Gutiérrez; Luis Cerdas;
Open Access English
  • Published: 01 Jan 1987
Abstract
1. The venom of the coral snake Micrurus nigrocinctus nigrocinctus was fractionated by reverse-phase high performance liquid chromatography and an acidic myotoxic phospholipase A2 was purified to homogeneity. 2. After intramuscular injection, the toxin induced rapid and drastic myonecrosis, as serum creatine kinase levels increased markedly, reaching their highest values by 1.5 hr. 3. Ultrastructural observations indicate that the plasma membrane was the first structure to be affected, with the presence of focal disruptions in its integrity. 4. Myofilaments were hypercontracted and formed dense clumps. Sarcoplasmic reticulum integrity was lost, as evidenced by t...
Subjects
free text keywords: Animals, Elapid venom, Mice, Microscopy, Muscles, Drug Effects, Necrosis, Phospholipases A2, Snake venom, Biochemistry, Physiology, Molecular Biology, General Medicine, Endoplasmic reticulum, medicine.symptom, medicine, Venom, Coral snake, biology.organism_classification, biology, Micrurus nigrocinctus, Phospholipase A2, biology.protein, Toxin, medicine.disease_cause
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publication . Article . 1987

Skeletal muscle necrosis induced by a phospholipase A2 isolated from the venom of the coral snake Micrurus nigrocinctus nigrocinctus

Olga Arroyo; Jean Pierre Rosso; Orietta Vargas; JoséMaría Gutiérrez; Luis Cerdas;