Skeletal muscle necrosis induced by a phospholipase A2 isolated from the venom of the coral snake Micrurus nigrocinctus nigrocinctus.

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Arroyo Gutiérrez, Olga; Rosso Julien, Jean Pierre; Vargas Rosso, Orietta; Gutiérrez, José María; Cerdas Fallas, Luis;
(1987)
  • Related identifiers: doi: 10.1016/0305-0491(87)90417-2
  • Subject: Animals | Elapid venom | Mice | Microscopy | Muscles | Drug Effects | Necrosis | Phospholipases A2 | Snake venom

1. The venom of the coral snake Micrurus nigrocinctus nigrocinctus was fractionated by reverse-phase high performance liquid chromatography and an acidic myotoxic phospholipase A2 was purified to homogeneity. 2. After intramuscular injection, the toxin induced rapid and... View more
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