publication . Article . 1999

Comparative study on the ability of IgG and F(ab')2 antivenoms to neutralize lethal and myotoxic effects induced by Micrurus nigrocinctus (coral snake) venom.

León, G.; Stiles, B.; Alape, A.; Rojas, G.; José María Gutiérrez;
Open Access
  • Published: 01 Aug 1999 Journal: The American Journal of Tropical Medicine and Hygiene, volume 61, pages 266-271 (issn: 0002-9637, eissn: 1476-1645, Copyright policy)
  • Publisher: American Society of Tropical Medicine and Hygiene
  • Country: Costa Rica
Abstract
A comparative study was performed on the ability of IgG and F(ab')2 antivenoms to neutralize lethal and myotoxic activities of Micrurus nigrocinctus venom. Both antivenoms were adjusted to a similar neutralizing potency in experiments where venom and antivenoms were preincubated prior to injection. No significant differences were observed between IgG and F(ab')2 antivenoms concerning neutralization of lethal effect in rescue experiments, i.e., when antivenom was administered intravenously after envenomation. However, F(ab')2 antivenom was more effective in prolonging the time of death when subneutralizing doses were administered immediately after venom injection...
Subjects
Medical Subject Headings: complex mixtures
free text keywords: Animals, Antibodies, Antivenins, Elapid Venoms, Elapidae, Enzyme-Linked Immunosorbent Assay, Immunoglobulin Fab Fragments, Immunoglobulin G, Injections, Intramuscular, Injections, Intraperitoneal, Injections, Intravenous, Lethal Dose 50, Mice, Neurotoxins, Neutralization Tests, Snake venom, Immunology, Median lethal dose, Neutralization, Myotoxin, Antivenom, Micrurus nigrocinctus, biology.organism_classification, biology, Venom, Envenomation
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publication . Article . 1999

Comparative study on the ability of IgG and F(ab')2 antivenoms to neutralize lethal and myotoxic effects induced by Micrurus nigrocinctus (coral snake) venom.

León, G.; Stiles, B.; Alape, A.; Rojas, G.; José María Gutiérrez;