publication . Conference object . Article . 2016

Role of inflammation gene polymorphisms on pain and response to radiotherapy in multiple myeloma patients with painful bone destructions.

Milda Rudzianskiene; Arturas Inciura; Rolandas Gerbutavicius; Ruta Dambrauskiene; Viktoras Rudzianskas; Elona Juozaityte;
Open Access English
  • Published: 20 May 2016
  • Country: Lithuania
Abstract
Background: Previous researches have demonstrated, that the severity of pain perception and it’s response to analgesia is highly dependent on gene polymorphism encoding for cytokines. We evaluated 12 single nucleotide polymorphisms (SNP) in 6 genes encoding for cytokines in multiple myeloma patients (n = 81) and assessed their influence on pain severity and response to palliative radiotherapy. Methods: Pain intensity was assessed by Visual Analogue Scale. The total dose of opioids was converted to a mean morphine-equivalent dose (mg/day). Pain intensity and dose of analgesics were evaluated before radiotherapy and 4, 12 and 24 weeks after the treatment. Analysis...
Subjects
free text keywords: Myeloma ; Radiotherapy ; Gene polymorphisms, 616-006.448 [udc], Cancer Research, Oncology, Bioinformatics, Gene, Multiple myeloma, medicine.disease, medicine, Gene polymorphism, Radiation therapy, medicine.medical_treatment, Pathology, medicine.medical_specialty, Pain perception, Inflammation, medicine.symptom, business.industry, business
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publication . Conference object . Article . 2016

Role of inflammation gene polymorphisms on pain and response to radiotherapy in multiple myeloma patients with painful bone destructions.

Milda Rudzianskiene; Arturas Inciura; Rolandas Gerbutavicius; Ruta Dambrauskiene; Viktoras Rudzianskas; Elona Juozaityte;