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Сочетанная трансплантация поджелудочной железы и почки: за и против

Сочетанная трансплантация поджелудочной железы и почки: за и против

Abstract

The review addresses the questions of history, clinical features and outcomes of simultaneous pancreas-kidney transplantation in patients with diabetes mellitus type 1. This approach was shown to have positive aspects, such as improvement of glycemic control, rapid normalization and long-term maintenance of glycated hemoglobin levels, disappearance of hypoglycemic events, and deceleration of coronary artery disease progression resulted in reduced incidence of cardiovascular mortality. Operative risk and post-transplantation complications are also described in details.

В статье приведен обзор клинических исследований, посвященных сочетанной трансплантации поджелудочной железы и почки у больных сахарным диабетом 1 типа. Показаны положительные аспекты данной операции, такие как снижение вариабельности гликемии, нормализация уровня гликированного гемоглобина, исчезновение эпизодов гипогликемических состояний, уменьшение прогрессии коронарного атеросклероза и, соответственно, снижение летальности от сердечно-сосудистой патологии. Даны подробные описания рисков и посттрансплантационных осложнений.

Keywords

САХАРНЫЙ ДИАБЕТ, СОЧЕТАННАЯ ТРАНСПЛАНТАЦИЯ ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ И ПОЧКИ, ИНСУЛИНОВАЯ ПОМПА, ГЛИКЕМИЧЕСКИЙ КОНТРОЛЬ, ТЕРМИНАЛЬНАЯ ПОЧЕЧНАЯ НЕДОСТАТОЧНОСТЬ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold