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Повесть о размерах дика зрительного нерва

Повесть о размерах дика зрительного нерва

Abstract

Objective: to compare the dependence of retinal nerve fiber layer thickness to the size of optic nerve head under confocal scanning laser ophthalmoscope and optical coherence tomography. Materials and methods: 201 outpatient’s cards with verified glaucoma diagnosis or with suspicion of glaucoma were retrospectively analysed. The average age is Me = 64 years (higher quartile is Q 56years, lower quartile is 72 years). A group of confocal scanning laser ophthalmoscope, which is 181eyes, and a group of optical coherence tomography, that is 183 eyes. Besides, all the groups were twice divided into 3 subgroups each, by means of cluster analysis and on the basis of size classification: large, medium and small. Results: according to the data of confocal scanning laser ophthalmoscope, the bigger is the optic nerve head, the less is retinal nerve fiber layer (Rs=-0,22; р=0,001). Conducting optical coherence tomography there is a different correlation, the bigger is the optic nerve head, the thicker is the retinal nerve fiber layer (Rs=0,15; р=0,03). Conclusion: the optic nerve head influences on the retinal nerve fiber layer thickness in both examinations: there is an inverse dependence while conducting confocal scanning laser ophthalmoscope that is the bigger the optic nerve head is, the less is the retinal nerve fiber layer, and there is a direct dependence while investigating optical coherence tomography the bigger is the optic nerve head, the thicker is retinal nerve fiber layer. It is important to take into consideration the size of the optical nerve head in the samplings while estimating retinal nerve fiber layer thickness.

Цель: сравнить зависимости толщины слоя нервных волокон сетчатки от размера диска зрительного нерва при конфокальной сканирующей лазерной офтальмоскопии и оптической когерентной томографии. Материалы и методы: ретроспективно проанализирована 201 карта пациентов с верифицированным диагнозом глаукома или подозрением на глаукому, средний возраст Me = 64 года (верхний квартиль Q 56, нижний квартиль Q 72 года). Группа конфокальной сканирующей лазерной офтальмоскопии 181 глаза, группа оптической когерентной томографии 183 глаз. Кроме того, все группы были дважды разделены на три подгруппы: при помощи кластерного анализа и на основании классификации: большие, средние, и малые. Результаты: слой нервных волокон сетчатки по данным конфокальной сканирующей лазерной офтальмоскопии тем меньше чем больше диск зрительного нерва (Rs=-0,22; р=0,001). А при проведении оптической когерентной томографии отмечается обратная взаимосвязь, чем больше диск зрительного нерва, тем толще слой нервных волокон сетчатки (Rs=0,15; р=0,03). Выводы: при обоих исследованиях размер диска зрительного нерва оказывает влияние на толщину слоя нервных волокон сетчатки: при конфокальной сканирующей лазерной офтальмоскопия обратная взаимосвязь, чем больше диск, тем тоньше слой нервных волокон сетчатки, а при оптической когерентной томографии, напротив, прямая связь, чем больше диск зрительного нерва, тем толще слой нервных волокон сетчатки. Таким образом, при оценке толщины слоя нервных волокон сетчатки в обоих исследованиях важно учитывать размер диска зрительного нерва в выборках.

Keywords

ГЛАУКОМА, КОНФОКАЛЬНАЯ СКАНИРУЮЩАЯ ЛАЗЕРНАЯ ОФТАЛЬМОСКОПИЯ, ОПТИЧЕСКАЯ КОГЕРЕНТНАЯ ТОМОГРАФИЯ, СЛОЙ НЕРВНЫХ ВОЛОКОН СЕТЧАТКИ, ДИСК ЗРИТЕЛЬНОГО НЕРВА

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average